The Role of the CDH1 Promoter Hypermethylation in the Axillary Lymph Node Metastasis and Prognosis
Identifieur interne : 003086 ( Main/Exploration ); précédent : 003085; suivant : 003087The Role of the CDH1 Promoter Hypermethylation in the Axillary Lymph Node Metastasis and Prognosis
Auteurs : Seung Pil Jung [Corée du Sud] ; Sangmin Kim [Corée du Sud] ; Seok Jin Nam [Corée du Sud] ; Insun Kim [Corée du Sud] ; Jeoung Won Bae [Corée du Sud]Source :
- Journal of Breast Cancer [ 1738-6756 ] ; 2013.
Abstract
Hypermethylation of the tumor suppressor genes is frequently observed in the tumor development and progression. However, the correlation between the hypermethylation of the tumor suppressor genes,
We selected a total of 122 paraffin-embedded specimens of the primary and paired metastatic lymph node from 61 breast cancer patients and analyzed the frequency of hypermethylation in the primary and metastatic lymph node using the methylation-specific polymerase chain reaction. In addition, the methylation status of
The hypermethylation of
This study suggests that hypermethylation of the
Url:
DOI: 10.4048/jbc.2013.16.1.16
PubMed: 23593077
PubMed Central: 3625765
Affiliations:
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last="Kim">Sangmin Kim</name><affiliation wicri:level="3"><nlm:aff id="A2">Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Nam, Seok Jin" sort="Nam, Seok Jin" uniqKey="Nam S" first="Seok Jin" last="Nam">Seok Jin Nam</name><affiliation wicri:level="3"><nlm:aff id="A2">Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Insun" sort="Kim, Insun" uniqKey="Kim I" first="Insun" last="Kim">Insun Kim</name><affiliation wicri:level="3"><nlm:aff id="A3">Department of Pathology, Korea University Hospital, Korea University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Pathology, Korea University Hospital, Korea University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Bae, Jeoung Won" sort="Bae, Jeoung Won" uniqKey="Bae J" first="Jeoung Won" last="Bae">Jeoung Won Bae</name><affiliation wicri:level="3"><nlm:aff id="A1">Division of Breast and Endocrine Surgery, Department of Surgery, Korea University Hospital, Korea University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Division of Breast and Endocrine Surgery, Department of Surgery, Korea University Hospital, Korea University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23593077</idno><idno type="pmc">3625765</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625765</idno><idno type="RBID">PMC:3625765</idno><idno type="doi">10.4048/jbc.2013.16.1.16</idno><date when="2013">2013</date><idno 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Prognosis</title><author><name sortKey="Jung, Seung Pil" sort="Jung, Seung Pil" uniqKey="Jung S" first="Seung Pil" last="Jung">Seung Pil Jung</name><affiliation wicri:level="3"><nlm:aff id="A1">Division of Breast and Endocrine Surgery, Department of Surgery, Korea University Hospital, Korea University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Division of Breast and Endocrine Surgery, Department of Surgery, Korea University Hospital, Korea University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Sangmin" sort="Kim, Sangmin" uniqKey="Kim S" first="Sangmin" last="Kim">Sangmin Kim</name><affiliation wicri:level="3"><nlm:aff id="A2">Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Nam, Seok Jin" sort="Nam, Seok Jin" uniqKey="Nam S" first="Seok Jin" last="Nam">Seok Jin Nam</name><affiliation wicri:level="3"><nlm:aff id="A2">Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Insun" sort="Kim, Insun" uniqKey="Kim I" first="Insun" last="Kim">Insun Kim</name><affiliation wicri:level="3"><nlm:aff id="A3">Department of Pathology, Korea University Hospital, Korea University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Pathology, Korea University Hospital, Korea University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Bae, Jeoung Won" sort="Bae, Jeoung Won" uniqKey="Bae J" first="Jeoung Won" last="Bae">Jeoung Won Bae</name><affiliation wicri:level="3"><nlm:aff id="A1">Division of Breast and Endocrine Surgery, Department of Surgery, Korea University Hospital, Korea University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Division of Breast and Endocrine Surgery, Department of Surgery, Korea University Hospital, Korea University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Breast Cancer</title><idno type="ISSN">1738-6756</idno><idno type="eISSN">2092-9900</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>Hypermethylation of the tumor suppressor genes is frequently observed in the tumor development and progression. However, the correlation between the hypermethylation of the tumor suppressor genes, <italic>CDH1</italic> and the axillary lymph node (ALN) metastasis is not fully elucidated. To verify the role of the <italic>CDH1</italic> promoter hypermethylation in the ALN metastasis and prognosis, we compared the methylation status of the <italic>CDH1</italic> genes in the primary lesion and the paired metastatic ALNs.</p></sec><sec><title>Methods</title><p>We selected a total of 122 paraffin-embedded specimens of the primary and paired metastatic lymph node from 61 breast cancer patients and analyzed the frequency of hypermethylation in the primary and metastatic lymph node using the methylation-specific polymerase chain reaction. In addition, the methylation status of <italic>CDH1</italic> was analyzed with the clinicopathologic characteristics, the disease-free survival and disease-specific survival.</p></sec><sec><title>Results</title><p>The hypermethylation of <italic>CDH1</italic> gene was identified in 54 (88.5%) of the 61 patients who had axillary metastasis. The hypermethylation status of the <italic>CDH1</italic> gene was significantly increased in the metastatic ALNs compared with that in the primary tumors (60.7% vs. 45.9%, <italic>p</italic><0.001). The hypermethylation status of the <italic>CDH1</italic> genes in the metastatic ALNs was associated with a poor histologic grade (<italic>p</italic>=0.041) and the patients who had methylated tumor in the primary lesion showed worse disease-free survival than the patients who did not have methylated tumor (<italic>p</italic>=0.046).</p></sec><sec><title>Conclusion</title><p>This study suggests that hypermethylation of the <italic>CDH1</italic> gene may play a pivotal role in the metastasis of the axillary lymph node and the breast cancer recurrence.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author><author><name sortKey="Center, Mm" uniqKey="Center M">MM Center</name></author><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Ward, E" uniqKey="Ward E">E 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sortKey="Lichtensztajn, D" uniqKey="Lichtensztajn D">D Lichtensztajn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ross, Js" uniqKey="Ross J">JS Ross</name></author><author><name sortKey="Fletcher, Ja" uniqKey="Fletcher J">JA Fletcher</name></author><author><name sortKey="Linette, Gp" uniqKey="Linette G">GP Linette</name></author><author><name sortKey="Stec, J" uniqKey="Stec J">J Stec</name></author><author><name sortKey="Clark, E" uniqKey="Clark E">E Clark</name></author><author><name sortKey="Ayers, M" uniqKey="Ayers M">M Ayers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berx, G" uniqKey="Berx G">G Berx</name></author><author><name sortKey="Van Roy, F" uniqKey="Van Roy F">F Van Roy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graff, Jr" uniqKey="Graff J">JR Graff</name></author><author><name sortKey="Herman, Jg" uniqKey="Herman J">JG Herman</name></author><author><name sortKey="Lapidus, Rg" uniqKey="Lapidus R">RG Lapidus</name></author><author><name sortKey="Chopra, H" uniqKey="Chopra H">H Chopra</name></author><author><name sortKey="Xu, R" uniqKey="Xu R">R Xu</name></author><author><name sortKey="Jarrard, Df" uniqKey="Jarrard D">DF Jarrard</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Jung, Seung Pil" sort="Jung, Seung Pil" uniqKey="Jung S" first="Seung Pil" last="Jung">Seung Pil Jung</name></region><name sortKey="Bae, Jeoung Won" sort="Bae, Jeoung Won" uniqKey="Bae J" first="Jeoung Won" last="Bae">Jeoung Won Bae</name><name sortKey="Kim, Insun" sort="Kim, Insun" uniqKey="Kim I" first="Insun" last="Kim">Insun Kim</name><name sortKey="Kim, Sangmin" sort="Kim, Sangmin" uniqKey="Kim S" first="Sangmin" last="Kim">Sangmin Kim</name><name sortKey="Nam, Seok Jin" sort="Nam, Seok Jin" uniqKey="Nam S" first="Seok Jin" last="Nam">Seok Jin Nam</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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